![]() In contrast, the level of activin βB mRNA and the percentage of immunoreactive cells for activin βB-subunit were higher before the secondary surge of FSH compared to other groups. Using quantitative reverse transcription-PCR, we showed that the levels of mRNA for BMP4, BMP receptor, the inhibitor of differentiation 2 ( Id2), a target gene of BMP4, and noggin did not change significantly across the estrous cycle. Ewes were killed in late follicular stage ( n=5), before the secondary FSH surge ( n=4), and in luteal phase ( n=4). The estrous cycles of ewes were synchronized with progestagen sponges. This work aimed at determining whether BMP4 and/or BMP receptor mRNA as well as activin/inhibin subunit mRNA fluctuates during the estrous cycle when FSHβ mRNA and FSH release changed. ![]() ![]() The detection of BMP4 mRNA and BMP receptors in the pituitary suggests that BMP4 can exert paracrine actions on FSH production. Recently, bone morphogenetic protein (BMP) 4 has been shown to inhibit FSH secretion in ewe. ![]()
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